“Creatine is more and more understood to be arguably an important complement individuals can take for general well being, and this patent provides to the mounting analysis underscoring its significance,” stated Mark Faulkner, founder and president of Vireo Programs. “I’m excited concerning the transformative potential this analysis has on the flexibility to strengthen the immune system and combat viruses, in addition to on different fields of well being.”
Registered with the U.S. Patent and Trademark workplace, the patent protects the corporate’s creatine formulations to be used in immune help therapies and merchandise for the following 20 years.
The patent analysis
The patent is predicated on analysis initiated in the course of the pandemic and features a major cell tradition research performed with the College of Manitoba, together with contributions to most cancers research at UCLA and Vanderbilt that yielded constant findings associated to the activation of T cells by way of creatine compounds. The core of the medical analysis is detailed within the patent software.
In short, Vireo Programs defined that its creatine hydrochloride (HCL) “facilitates the entry of antiviral substances into cells, strengthening the physique’s virus-fighting functionality whereas minimizing irritation brought on by viral proteins”. The analysis additionally reveals that creatine and related compounds present the physique with the power to mount a robust immune response in opposition to viral infections.
The corporate attributes this functionality to what it claims is vastly enhanced bioavailability of its creatine HCL in comparison with commonplace creatine monohydrate. Its improved solubility and permeability resulted in 70% extra absorption into the bloodstream, in response to findings from a 2013 research led by Donald Miller, PhD, professor in pharmacology and therapeutics on the College of Manitoba and Vireo Programs board member.
“Different types of creatine may probably supply immune help if they may successfully attain the bloodstream,” Faulkner stated. “Nonetheless, what units CON-CRĒT Creatine HCL aside is its outstanding capacity to realize superior absorption in comparison with older creatine formulations (i.e., creatine monohydrate).”
Forthcoming analysis will embrace animal testing to additional display the efficacy of sure compounds in opposition to viruses and to optimize dosing and formulation through the use of a mixture of creatine conjugations to supply higher and focused immune help.
“The way forward for creatine remedy for immune well being will undoubtedly draw closely from the information introduced on this patent,” Faulkner added. “Moreover, we anticipate the upcoming follow-on patent, anticipated to be granted subsequent 12 months, will delve deeper into the mobile energetics influenced by creatine, enabling cells to perform extra successfully and keep higher general well being and resilience.”
First immune complement with creatine
Vireo Programs, based mostly in Nashville, TN, launched a multi-ingredient components in 2020 as “the primary immune help complement with creatine” beneath newly developed product division Promera Well being Immune Help, however Faulkner stated that the corporate determined to modify gears given creatine’s potential as a novel standalone immune well being ingredient.
“We swiftly redirected our focus away from Promera Well being Immune Help—and to the brand new analysis —as a result of it fell inside a extremely aggressive market section, and its effectiveness might be attributed to the a number of helpful substances it contained.”
Along with CON-CRĒT, the components included immune boosters like Vitamin D, zinc, selenium, black elderberry and inexperienced tea extracts in addition to Alpha-GEE, Vireo System’s patented amino acid-based peptide that helps wholesome irritation responses.
“This considerably obscured the outstanding efficacy and significance of the creatine part inside the components,” Faulkner added. “We imagine that the creatine is the first driver behind the substantial and overarching optimistic affect on the immune system’s Killer T Cells, and we wished to emphasise its essential position with out dilution from different substances.”
Future creatine-powered immune help merchandise will launch beneath the Vireo and CON-CRĒT product strains.